Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges

Blood Cancer Discov. 2024 Mar 1;5(2):86-89. doi: 10.1158/2643-3230.BCD-23-0212.


Single-cell RNA sequencing has emerged as a powerful technique to understand the molecular features of chimeric antigen receptor (CAR) T cells that associate with clinical outcomes. Here we discuss the common themes that have emerged from across single-cell studies of CAR T-cell therapy, and summarize the challenges in interpreting this complex data type.

MeSH terms

  • Humans
  • Immunotherapy, Adoptive*
  • Research Personnel*