Population dynamics and chemotherapeutic control of Trichuris trichiura infection of children in Jamaica and St. Lucia

Trans R Soc Trop Med Hyg. 1985;79(6):759-64. doi: 10.1016/0035-9203(85)90110-5.

Abstract

Population dynamical parameters of Trichuris trichiura infections in children were estimated from longitudinal intensity and prevalence data from a population (n = 23) in a children's home in Jamaica. The theoretical predictions of a deterministic model incorporating these parameters were approximated to observed horizontal-age prevalence data from a naturally infected population (n = 203) of children in a St. Lucian village, and a rough estimate of the basic reproductive rate (Ro = 8-10) of T. trichiura obtained. The findings suggest that T. trichiura populations are intrinsically more difficult to control by traditional mass-treatment chemotherapy (eradication requires greater than 91% of the population to be treated every 6 months for greater than 5 years) than are populations of Ascaris, but may be more susceptible to selective chemotherapy programmes which aim to treat only the most heavily infected individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Child
  • Child, Preschool
  • Feces / parasitology
  • Female
  • Humans
  • Infant
  • Jamaica
  • Male
  • Mebendazole / therapeutic use
  • Models, Biological
  • Parasite Egg Count
  • Population Dynamics
  • Recurrence
  • Trichuriasis / drug therapy*
  • Trichuriasis / epidemiology
  • Trichuriasis / parasitology
  • Trichuris / growth & development
  • West Indies

Substances

  • Mebendazole