The combination of ipilimumab and nivolumab is still not reimbursed for BRAF-mutated melanoma patients in France: An unacceptable medical situation that raises ethical concerns

M Amini-Adle; J-P Arnault; F Aubin; N Beneton; G Bens; F Brunet-Possenti; P Célerier; J Charles; L Crumbach; S Dalac; S Darras; J De Quatrebarbes; M Dinulescu; C Dutriaux; C Gaudy; E Gérard; D Giacchero; F Granel-Brocard; F Grange; T Jouary; N Kramkimel; C Lebbé; Y Le Corre; D Legoupil; C Lesage; T Lesimple; J-M Lorphelin; S Mansard; L Martin; S Mary-Prey; E Maubec; N Meyer; C Mignard; H Montaudie; L Mortier; C Nardin; E-M Neidhardt Berard; C Pagès Laurent; L Peuvrel; Gaelle Quereux; Caroline Robert; Philippe Saiag; Mélanie Saint-Jean; M Samimi; B Sassolas; C Scalbert; F Skowron; M Steff; P-E Stoebner; S Trablesi; L Visseaux; O Zehou; A Boespflug; GCC group Groupe Cancérologie Cutanée – Cutaneous Oncology Group, the Ethical Group of the Société Française de Dermatologie French Dermatology Group

doi:10.1016/j.annder.2023.103243

The combination of ipilimumab and nivolumab is still not reimbursed for BRAF-mutated melanoma patients in France: An unacceptable medical situation that raises ethical concerns

Ann Dermatol Venereol. 2024 Mar;151(1):103243. doi: 10.1016/j.annder.2023.103243. Epub 2024 Feb 6.

Authors

M Amini-Adle¹, J-P Arnault², F Aubin³, N Beneton⁴, G Bens⁵, F Brunet-Possenti⁶, P Célerier⁷, J Charles⁸, L Crumbach⁹, S Dalac¹⁰, S Darras¹¹, J De Quatrebarbes¹², M Dinulescu¹³, C Dutriaux¹⁴, C Gaudy¹⁵, E Gérard¹⁴, D Giacchero¹⁶, F Granel-Brocard¹⁷, F Grange¹⁸, T Jouary¹⁹, N Kramkimel²⁰, C Lebbé²¹, Y Le Corre²², D Legoupil²³, C Lesage²⁴, T Lesimple²⁵, J-M Lorphelin²⁶, S Mansard²⁷, L Martin²⁸, S Mary-Prey²⁹, E Maubec³⁰, N Meyer³¹, C Mignard³², H Montaudie³³, L Mortier³⁴, C Nardin³⁵, E-M Neidhardt Berard⁹, C Pagès Laurent³¹, L Peuvrel³⁶, Gaelle Quereux³⁷, Caroline Robert³⁸, Philippe Saiag³⁹, Mélanie Saint-Jean³⁶, M Samimi⁴⁰, B Sassolas⁴¹, C Scalbert⁴², F Skowron⁴³, M Steff⁴⁴, P-E Stoebner⁴⁵, S Trablesi⁸, L Visseaux⁴⁶, O Zehou⁴⁷, A Boespflug⁴⁸; GCC group Groupe Cancérologie Cutanée – Cutaneous Oncology Group, the Ethical Group of the Société Française de Dermatologie French Dermatology Group

Affiliations

¹ Dermatology Department, Centre Léon Bérard, Lyon, France. Electronic address: mona.amini-adle@lyon.unicancer.fr.
² Dermatology Department, Centre Hospitalo-Universitaire, Amiens Picardie, France.
³ Université de Bourgogne-Franche-Comté, Dermatology Department, Head of the Skin Cancer Unit, Centre Hospitalo-Universitaire de Besançon, Besançon, France; INSERM UMR RIGHT 1098, Besançon, France.
⁴ Dermatology Department, Centre Hospitalier, Le Mans, France.
⁵ Dermatology Department, Centre Hospitalier, Orléans, France.
⁶ Dermatology Department, Centre Hospitalo-Universitaire Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France.
⁷ Dermatology Department, Centre Hospitalier La Rochelle-Ré-Aunis, La Rochelle, France.
⁸ Dermatology Department, Centre Hospitalo-Universitaire, Grenoble, France.
⁹ Dermatology Department, Centre Léon Bérard, Lyon, France.
¹⁰ Dermatology Department, Centre Hospitalo-Universitaire, Dijon, France.
¹¹ Dermatology Department, Centre Hospitalier de Boulogne-sur-Mer, France.
¹² Dermatology Department, Centre Hospitalier Annecy Genevois, Annecy, France.
¹³ Dermatology Department, Centre Hospitalo-Universitaire, Rennes, France.
¹⁴ Dermatology Department, Centre Hospitalo-Universitaire, Bordeaux, France.
¹⁵ Dermatology Department, Centre Hospitalo-Universitaire, Marseille, France.
¹⁶ Centre Antoine Lacassagne, Nice, France.
¹⁷ Dermatology Department, Hôpitaux de Brabois Allée de Morvan, Vandoeuvre Les Nancy, France.
¹⁸ Dermatology Department, Centre Hospitalier, Valence, France.
¹⁹ Dermatology Department, Hôpital François Mitterrand, Pau, France.
²⁰ Dermatology Department, Centre Hospitalo-Universitaire Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
²¹ Dermatology Department, Centre Hospitalo-Universitaire Saint Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
²² Dermatology Department, Centre Hospitalo-Universitaire Angers, France.
²³ Dermatology Department, Centre Hospitalo-Universitaire Régional, Brest, France.
²⁴ Dermatology Department, Hôpital Saint Eloi, Montpellier, France.
²⁵ Centre Eugene Marquis, Rennes, France.
²⁶ Dermatology Department, Centre Hospitalo-Universitaire, Caen, France.
²⁷ Dermatology Department, Centre Hospitalo-Universitaire, Clermont Ferrand, France.
²⁸ Dermatology Department, Centre Hospitalo-Universitaire, Angers, France; Groupe Ethique de la Société Française de Dermatologie, France.
²⁹ Centre Hospitalo-Universitaire Saint André, Bordeaux, France.
³⁰ Dermatology Department, Centre Hospitalo-Universitaire Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
³¹ Institut Universitaire du Cancer et Centre Hospitalo-Universitaire, Toulouse, France.
³² Dermatology Department, Centre Hospitalo-Universitaire, Rouen, France.
³³ Dermatology Department, Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Nice, France; INSERM U1065, Team 12, Centre Méditerranéen de Médecine Moléculaire, Université Nice Côte d'Azur, Nice, France.
³⁴ Dermatology Department, Centre Hospitalier Régional Universitaire, Lille, France.
³⁵ Université de Bourgogne-Franche-Comté et Centre Hospitalier Universitaire, Besançon, France; IINSERM UMR RIGHT 1098, Besançon, France.
³⁶ Medical Oncology Department, Institut de Cancérologie de l'Ouest, Saint Herblain, France.
³⁷ Dermatology Department, Centre Hospitalo-Universitaire, Nantes Université, Nantes, France; INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302, Nantes, France.
³⁸ Dermatology Department, Institut Gustave Roussy, Villejuif, France.
³⁹ Dermatology Department, Centre Hospitalo-Universitaire Ambroise Paré, Assistance Publique-Hôpitaux de Paris, Boulogne Billancourt, France.
⁴⁰ Dermatology Department, Centre Hospitalo-Universitaire, Tours, France.
⁴¹ Institute of Oncology & Hematology, Hôpital Morvan, Centre Hospitalier Régional Universitaire, Brest, France.
⁴² Dermatology Department, Centre Hospitalier Ouest Réunion, Saint Paul, Ile de la Réunion, France.
⁴³ Dermatology Department, Hôpitaux Drome Nord, Romans Sur Isère, France.
⁴⁴ Dermatology Department, Centre Hospitalier Intercommunal Robert Ballanger, Aulnay sous-Bois, France.
⁴⁵ Dermatology Department, Centre Hospitalo-Universitaire, Nîmes, France.
⁴⁶ Polyclinique Reims Bezannes, Bezannes, France.
⁴⁷ Dermatology Department, Centre Hospitalo-Universitaire Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.
⁴⁸ Dermatology Department, Centre Hospitalier Henri Mondor, Villejuif, France.

PMID: 38325268
DOI: 10.1016/j.annder.2023.103243

No abstract available

Keywords: BRAF mutation; Ipilimumab; Metastatic melanoma; Nivolumab; Reimbursement.

Publication types

Letter

MeSH terms

Antineoplastic Combined Chemotherapy Protocols
France
Humans
Ipilimumab / therapeutic use
Melanoma* / drug therapy
Melanoma* / genetics
Nivolumab / therapeutic use
Proto-Oncogene Proteins B-raf / genetics
Skin Neoplasms* / drug therapy
Skin Neoplasms* / genetics

Substances

Nivolumab
Ipilimumab
Proto-Oncogene Proteins B-raf
BRAF protein, human