[Co-existence of AML1-ETO and BCR-ABL1 fusion genes in acute myeloid leukemia: a case report]

Zhonghua Nei Ke Za Zhi. 2024 Feb 1;63(2):203-206. doi: 10.3760/cma.j.cn112138-20230815-00059.

[Article in Chinese]

Authors

Y Q Yao¹, X Jia¹, H Liu¹, Q S Lu², W J Xiong², Y Zhang¹, Q F Liu¹, P C Shi¹

Affiliations

¹ Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
² Foresea Life Insurance Guangzhou General Hospital, Guangzhou 511300, China.

PMID: 38326048
DOI: 10.3760/cma.j.cn112138-20230815-00059

Abstract

报道1例同时伴有AML1-ETO和BCR-ABL1融合基因的急性髓系白血病罕见病例。BCR-ABL1可能协同AML1-ETO融合基因促进白血病发生发展。化疗联合达沙替尼靶向治疗可早期获得完全分子生物学缓解，序贯异基因造血干细胞移植有可能获得长期生存。.

Publication types

Case Reports

MeSH terms

Core Binding Factor Alpha 2 Subunit / genetics
Humans
Leukemia, Myeloid, Acute* / genetics
Oncogene Proteins, Fusion / genetics
RUNX1 Translocation Partner 1 Protein / genetics

Substances

RUNX1 Translocation Partner 1 Protein
Core Binding Factor Alpha 2 Subunit
AML1-ETO fusion protein, human
Oncogene Proteins, Fusion