Intravenous self-administration of ethanol and acetaldehyde by rats

Yakubutsu Seishin Kodo. 1985 Dec;5(4):329-34.

Abstract

Fisher strain rats were allowed to self-administer 2, 6, and 18 microM/kg/infusion of ethanol and acetaldehyde into the jugular vein for 22 to 28 days. Thirty-three percent of the rats self-administered 18 microM/kg/infusion of ethanol. Thirty-three, 40, and 33 percent of the rats initiated self-administration of 2, 6, and 18 microM/kg/infusion of acetaldehyde, respectively. It is suggested that acetaldehyde may possess stronger reinforcing effects than ethanol in intravenous self-administration by rats.

MeSH terms

  • Acetaldehyde / analysis
  • Acetaldehyde / pharmacology*
  • Animals
  • Brain / drug effects*
  • Brain Chemistry
  • Ethanol / metabolism
  • Ethanol / pharmacology*
  • Injections, Intraventricular
  • Male
  • Rats
  • Reinforcement, Psychology
  • Self Administration

Substances

  • Ethanol
  • Acetaldehyde