Multifunctional Cu2 Se/F127 Hydrogel with SOD-Like Enzyme Activity for Efficient Wound Healing

Jia He; Wei Zhang; Yuyu Cui; Liang Cheng; Xu-Lin Chen; Xianwen Wang

doi:10.1002/adhm.202303599

Multifunctional Cu₂ Se/F127 Hydrogel with SOD-Like Enzyme Activity for Efficient Wound Healing

Adv Healthc Mater. 2024 Feb 8:e2303599. doi: 10.1002/adhm.202303599. Online ahead of print.

Authors

Jia He¹, Wei Zhang², Yuyu Cui¹, Liang Cheng³, Xu-Lin Chen¹, Xianwen Wang^{2

4}

Affiliations

¹ Department of Burns, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
² School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, China.
³ Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou, 215123, China.
⁴ College and Hospital of Stomatology, Key Lab. of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, 230032, P. R. China.

PMID: 38331398
DOI: 10.1002/adhm.202303599

Abstract

Free radicals are secreted following skin damage and cause oxidative stress and inflammatory reactions that increase the difficulty of wound healing. In this study, copper-based nanozyme Cu₂ Se nanosheets (NSs) are synthesized by an anion-exchange strategy and apply to wounds with F127 hydrogels to investigate the healing effect of this nanozyme composite hydrogels on wounds. Cu₂ Se NSs have a large number of catalytically active centers, are simple to synthesize, require few reaction conditions and have a short synthesis cycle. In vitro experiments have shown that Cu₂ Se NSs possess superoxide dismutase (SOD)-like activity and nitrogen radical scavenging activity and promote angiogenesis and fibroblast migration. The doping of Cu₂ Se NSs into the F127 hydrogel does not have a significantly affect on the properties of the hydrogel. This hybridized hydrogel not only adapts to the irregular and complex morphology of acute wounds but also prolongs the duration of nanozyme action on the wound, thus promoting wound healing. Transcriptomic analysis further reveals the potential therapeutic mechanism of the Cu₂ Se/F127 hydrogel in promoting acute wound healing. Animal experiments have shown that the Cu₂ Se/F127 hydrogel has good biosafety. The Cu₂ Se/F127 hydrogel provides an innovative idea for the development of hydrogel dressings for the treatment of acute wounds.

Keywords: Cu2Se; anti-inflammatory; hydrogels; nanozymes; wound healing.

Abstract

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