Tibial dyschondroplasia in single-comb White Leghorn chicks fed tetramethylthiuram disulfide (a fungicide)

Avian Dis. Oct-Dec 1985;29(4):1269-72.

Abstract

Supplementing a practical chick starter diet with 30 mg tetramethylthiuram disulfide per kg of diet produced tibial dyschondroplasia (TD) in single-comb white leghorn chicks without compromising growth or bone mineralization. The incidence and severity of the lesion increased over time, with the highest incidence (40%) occurring in 4-week-old chickens. Microscopically, the lesion was consistent with the description of TD in broilers. This is the first known report of TD in the layer-type chick, which heretofore was felt to be highly resistant to TD.

MeSH terms

  • Animals
  • Chickens
  • Osteochondrodysplasias / chemically induced
  • Osteochondrodysplasias / veterinary*
  • Poultry Diseases / chemically induced*
  • Thiocarbamates / adverse effects*
  • Thiram / adverse effects*
  • Tibia / drug effects
  • Tibia / pathology
  • Time Factors

Substances

  • Thiocarbamates
  • Thiram