Synthesis and crystal structure of N1, N2-di-methyl-ethane-dihydrazide

Yurii S Bibik; Dmytro M Khomenko; Roman O Doroshchuk; Ilona V Raspertova; Alexandra Bargan; Rostyslav D Lampeka

doi:10.1107/S2056989024000239

Synthesis and crystal structure of N¹, N²-di-methyl-ethane-dihydrazide

Acta Crystallogr E Crystallogr Commun. 2024 Jan 12;80(Pt 2):148-151. doi: 10.1107/S2056989024000239. eCollection 2024 Feb 1.

Authors

Yurii S Bibik¹, Dmytro M Khomenko^{1

2}, Roman O Doroshchuk^{1

2}, Ilona V Raspertova^{1

2}, Alexandra Bargan³, Rostyslav D Lampeka¹

Affiliations

¹ Department of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska St 64, Kyiv, Ukraine.
² Enamine Ltd., Winston Churchill St 78, Kyiv 02094, Ukraine.
³ "Petru Poni" Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41A, 700487 Iasi, Romania.

Abstract

The title compound, N ¹,N ²-di-methyl-ethane-dihydrazide, C₄H₁₀N₄O₂, was obtained by the methyl-ation of oxalyl dihydrazide protected with phthalimide. The mol-ecule is essentially non-planar with a dihedral angle between the two planar hydrazide fragments of 86.5 (2)°. This geometry contributes to the formation of a multi-contact three-dimensional supra-molecular network via C-H⋯O, N-H⋯O and N-H⋯N hydrogen bonds.

Keywords: X-ray crystallography; crystal structure; hydrazide; hydrogen bonds.

Grants and funding

Funding for this research was provided by: Ministry of Education and Science of Ukraine (grant for the perspective development of the scientific direction ‘Mathematical sciences and natural sciences’ and grant No. 22BF037-06 at the Taras Shevchenko National University of Kyiv); Ministry of Research, Innovation and Digitization (Romania), CCCDI - UEFISCDI, project number PN-III-P2-2.1-PED-2021-3900, within PNCDI III, Contract PED 698/2022 (AI-Syn-PPOSS).