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. 2024 Jan 30;13(3):799.
doi: 10.3390/jcm13030799.

Circuit Training Improves the Levels of β-Amyloid and Brain-Derived Neurotrophic Factor Related to Cognitive Impairment Risk Factors in Obese Elderly Korean Women

Duwang Kang  1 , Suhan Koh  1 , Taekyu Kim  1 , Eadric Bressel  2 , Doyeon Kim  1
Affiliations

Circuit Training Improves the Levels of β-Amyloid and Brain-Derived Neurotrophic Factor Related to Cognitive Impairment Risk Factors in Obese Elderly Korean Women

Duwang Kang et al. J Clin Med. .

Abstract

Background: The purpose of this study was to investigate the effect of circuit training on β-amyloid, BDNF, and cognitive function in untrained obese elderly Korean women. Methods: The subjects for the study were aged 65-70 years and were each assigned to a circuit training group (EG, n = 12) or a control group (CG, n = 11). The 60 min combined exercise was performed 3 times per week for 16 weeks. The exercise intensity was progressively increased from a 40% heart rate reserve to a 70% heart rate reserve. The test data were analyzed using a paired t-test, an independent t-test, and a two-way repeated measures ANOVA, and an alpha level of 0.05 was set for all tests of significance. Results: Group-by-time interaction effects were observed for β-amyloid (p < 0.05), brain-derived neurotrophic factor (p < 0.01), and cognitive function (p < 0.05). Within the exercise group, significant differences were found in β-amyloid (p < 0.05), brain-derived neurotrophic factor (p < 0.001), and cognitive function (p < 0.05) when comparing across different time points. Additionally, there were statistically significant differences between groups in post-exercise β-amyloid (p < 0.05), change in β-amyloid (p < 0.05), brain-derived neurotrophic factor (p < 0.01), and cognitive function (p < 0.05). Conclusions: Therefore, it is suggested that the circuit training used in this study could be an effective exercise method for improving the risk factors of cognitive impairment in obese elderly Korean women.

Keywords: brain-derived neurotrophic factor; circuit training; cognitive function; obese elderly women; β-amyloid.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Procedures of this study.
Figure 2
Figure 2
Flowchart of exercise intervention.
Figure 3
Figure 3
Comparisons of β-amyloid after 16-week circuit training. * p < 0.05: pre vs. post; # p < 0.05: exercise vs. control.
Figure 4
Figure 4
Result of two-way repeated measures ANOVA of β-amyloid after 16-week circuit training.
Figure 5
Figure 5
Comparisons of BDNF after 16-week circuit training. *** p < 0.001: pre vs. post; ## p < 0.01: exercise vs. control.
Figure 6
Figure 6
Result of two-way repeated measures ANOVA of BDNF after 16-week circuit training.
Figure 7
Figure 7
Comparisons of MMSE-K after 16-week circuit training. * p < 0.05: pre vs. post; # p < 0.05: exercise vs. control.
Figure 8
Figure 8
Result of two-way repeated measures ANOVA of MMSE-K after 16-week circuit training.
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