Scarring Skin: Mechanisms and Therapies

Int J Mol Sci. 2024 Jan 25;25(3):1458. doi: 10.3390/ijms25031458.


Skin injury always results in fibrotic, non-functional scars in adults. Although multiple factors are well-known contributors to scar formation, the precise underlying mechanisms remain elusive. This review aims to elucidate the intricacies of the wound healing process, summarize the known factors driving skin cells in wounds toward a scarring fate, and particularly to discuss the impact of fibroblast heterogeneity on scar formation. To the end, we explore potential therapeutic interventions used in the treatment of scarring wounds.

Keywords: fibroblast heterogeneity; scar formation; scar treatments.

Publication types

  • Review

MeSH terms

  • Adult
  • Cicatrix* / pathology
  • Cicatrix* / therapy
  • Fibroblasts / pathology
  • Humans
  • Skin* / pathology
  • Wound Healing