Biocompatible, Injectable, and Self-Healing Poly(N-vinylpyrrolidone)/Carboxymethyl Cellulose Hydrogel for Drug Release

Zuwu Tang; Yuqing Yang; Yuwei Pan; Meiqiong Yu; Xinxing Lin; Ajoy Kanti Mondal

doi:10.1021/acsomega.3c09156

Biocompatible, Injectable, and Self-Healing Poly(N-vinylpyrrolidone)/Carboxymethyl Cellulose Hydrogel for Drug Release

ACS Omega. 2024 Jan 26;9(5):5854-5861. doi: 10.1021/acsomega.3c09156. eCollection 2024 Feb 6.

Authors

Zuwu Tang¹, Yuqing Yang¹, Yuwei Pan¹, Meiqiong Yu^{1

2}, Xinxing Lin¹, Ajoy Kanti Mondal³

Affiliations

¹ School of Materials and Packaging Engineering, Fujian Polytechnic Normal University, Fuzhou, Fujian 350300, P. R. China.
² College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350108, P. R. China.
³ Institute of National Analytical Research and Service, Bangladesh Council of Scientific and Industrial Research, Dhanmondi, Dhaka 1205, Bangladesh.

Abstract

Hydrogels have drawn intensive attention as fascinating materials for biomedicine. However, fabricating hydrogels with injectable and self-healing properties remains a challenge. Herein, we reported a biocompatible poly(N-vinylpyrrolidone)/carboxymethyl cellulose (PVP/CMC) hydrogel with excellent injectable and self-healing properties. The PVP/CMC hydrogel exhibits good biocompatible, injectable, and self-healing properties. The sol-gel transition of PVP/CMC hydrogels demonstrates an outstanding self-healing behavior, and the bisected hydrogels can self-heal within 30 s. The hydrogels have a good swelling ratio, and the swelling ratio increases with increasing amount of CMC in PVP and reaches a maximum of 2850% at a 1.0:1.5 PVP and CMC ratio. In addition, the hydrogel possesses excellent drug release capacity, and its drug release rate reaches 70%. Moreover, the release of 4-aminosalicylic acid (4-ASA) in the hydrogel can be controlled by adjusting the proportion of the hydrogel. The PVP/CMC hydrogel with excellent biocompatible, injectable, and self-healing properties has great potential for applications in drug release.