Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Rongxue Wei; Yongqiang Teng; Chunchun Han; Shouhai Wei; Liang Li; Hehe Liu; Shenqiang Hu; Bo Kang; Hengyong Xu

doi:10.3389/fvets.2024.1122904

Multi-omics reveals goose fatty liver formation from metabolic reprogramming

Front Vet Sci. 2024 Jan 29:11:1122904. doi: 10.3389/fvets.2024.1122904. eCollection 2024.

Authors

Rongxue Wei^#^{1

2}, Yongqiang Teng^#^{1

2}, Chunchun Han^{1

2}, Shouhai Wei^{1

2}, Liang Li^{1

2}, Hehe Liu^{1

2}, Shenqiang Hu^{1

2}, Bo Kang^{1

2}, Hengyong Xu^{1

2}

Affiliations

¹ Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
² Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.

^# Contributed equally.

Abstract

To comprehensively provide insight into goose fatty liver formation, we performed an integrative analysis of the liver transcriptome, lipidome, and amino acid metabolome, as well as peripheral adipose tissue transcriptome analysis using samples collected from the overfed geese and normally fed geese. Transcriptome analysis showed that liver metabolism pathways were mainly enriched in glucolipid metabolism, amino acid metabolism, inflammation response, and cell cycle; peripheral adipose tissue and the liver cooperatively regulated liver lipid accumulation during overfeeding. Liver lipidome patterns obviously changed after overfeeding, and 157 different lipids were yielded. In the liver amino acid metabolome, the level of Lys increased after overfeeding. In summary, this is the first study describing goose fatty liver formation from an integrative analysis of transcriptome, lipidome, and amino acid metabolome, which will provide a whole new dimension to understanding the mechanism of goose fatty liver formation.

Keywords: amino acid metabolome; goose fatty liver; lipidome; peripheral adipose tissue; transcriptome.

Associated data

figshare/10.6084/m9.figshare.21154540

Grants and funding

The work was supported by the National Natural Science Funds of China (No. 31672413), and the Natural Science Funds of Sichuan Province (No. 2022NSFSC0059).