Preoperative depression and anxiety associated with younger age and receipt of immediate breast reconstruction

Am J Surg. 2024 May:231:106-112. doi: 10.1016/j.amjsurg.2024.02.012. Epub 2024 Feb 8.


Background: As survivorship for breast cancer continues to improve, emphasis of care falls upon improving patients' quality of life. Understanding physical and mental health in the preoperative period is needed to aid surgical decision making and improve patient experience.

Methods: Consecutive patients awaiting total mastectomy (TM), TM with immediate breast reconstruction (IBR) and breast conserving surgery (BCS) were prospectively recruited. Scores for PHQ-9, GAD-7, Breast-Q, EQ5D(5L), PEG were collected preoperatively. Association was measured with multivariate analyses.

Results: 477 participants (374 BSC, 46 ​TM, 84 IBR) were included. Younger patients and those choosing IBR reported worse depression and anxiety symptoms. Clinical tumor features did not affect patient reported outcomes. Higher Breast-Q scores were seen with BCS and lower scores with TM.

Conclusions: Patients scheduled for IBR and younger patients reported worse symptoms of depression and anxiety, regardless of clinical features. This will help with surgical decision making and identify patients in need for additional perioperative supports.

Keywords: Breast cancer; Breast conserving surgery; Health-related quality of life; Immediate breast reconstruction; Patient reported outcomes; Total mastectomy.

MeSH terms

  • Anxiety / epidemiology
  • Anxiety / etiology
  • Breast Neoplasms* / surgery
  • Depression / epidemiology
  • Depression / etiology
  • Female
  • Humans
  • Mammaplasty*
  • Mastectomy / psychology
  • Quality of Life