Association between serum triglyceride level and severity of acute biliary pancreatitis

Qian Zhang; Qingcheng Xu; Quping Zhu; Lei Zhu; Changbao Pan; Juan Chen; Jun Liu; Denghao Deng; Weiwei Chen; Chaowu Chen

doi:10.1016/j.pan.2024.02.001

Association between serum triglyceride level and severity of acute biliary pancreatitis

Pancreatology. 2024 May;24(3):343-349. doi: 10.1016/j.pan.2024.02.001. Epub 2024 Feb 6.

Authors

Qian Zhang¹, Qingcheng Xu¹, Quping Zhu¹, Lei Zhu¹, Changbao Pan¹, Juan Chen¹, Jun Liu¹, Denghao Deng¹, Weiwei Chen², Chaowu Chen³

Affiliations

¹ Department of Gastroenterology, Clinical Medical College, Yangzhou University, Yangzhou, 225001, Jiangsu Province, China.
² Department of Gastroenterology, Clinical Medical College, Yangzhou University, Yangzhou, 225001, Jiangsu Province, China. Electronic address: cww1984@126.com.
³ Department of Gastroenterology, Clinical Medical College, Yangzhou University, Yangzhou, 225001, Jiangsu Province, China. Electronic address: doctor_ccw@163.com.

PMID: 38350790
DOI: 10.1016/j.pan.2024.02.001

Abstract

Background: Acute biliary pancreatitis (ABP) is the most common type of acute pancreatitis. However, the effect of serum triglyceride (TG) levels on the severity of ABP remains unclear. The aim of this study was to assess the correlation between serum TG levels and the severity of ABP.

Methods: Data from 526 ABP patients was analyzed in this study. The patients were divided into normal and elevated groups according to the TG level measured within 24 h after admission, and the elevated group was further divided into mild, moderate, and severe elevated groups. The demographic data and clinical outcomes of each group were compared.

Results: Of the 526 ABP patients, 394 were in the normal TG group and 132 were in the elevated TG group (36 mild, 57 moderate, and 39 severe). The elevated group was younger (51.5 ± 12.9 vs. 58.9 ± 13.9), predominantly male (66.7% vs. 45.2%), had more history of diabetes (22.7% vs. 12.4%) and hyperlipidemia (19.7% vs. 0.8%), and developed systemic inflammatory response syndrome (SIRS) (25.8% vs. 15.5%), persistent organ failure (POF) (11.4% vs. 2.8%), and local complications (62.9% vs. 42.1%) more frequently compared to the normal group (P < 0.05). The incidence of SIRS, POF, acute peripancreatic fluid collection (APFC), and acute necrotic collection (ANC) increased with increasing TG levels (P_trend < 0.05). In multivariate analysis, TG was independently associated with POF, APFC, and ANC in increments of 100 mg/dl (P < 0.05), and there was a linear relationship between TG levels and POF, APFC, and ANC (non-linear P > 0.05, P overall <0.05). In addition, nonalcoholic fatty liver disease is not a risk factor for POF, ANC, and APFC in ABP patients.

Conclusions: Elevated serum TG levels were independently associated with more severe ABP. The incidence of POF, APFC, and ANC in ABP patients increased with the increase of TG levels, with a linear relationship.

Keywords: Acute biliary pancreatitis; Acute pancreatitis; Triglyceride.

MeSH terms

Acute Disease
Female
Humans
Male
Pancreatitis* / complications
Retrospective Studies
Systemic Inflammatory Response Syndrome / complications
Triglycerides

Substances

Triglycerides