Ambient ultraviolet radiation and ocular melanoma incidence in the United States, 2000-2019

Basilica M Arockiaraj; Elizabeth K Cahoon; Michael R Sargen; Erping Long; Margaret A Tucker; Jim Z Mai

doi:10.1038/s41433-024-02959-9

Ambient ultraviolet radiation and ocular melanoma incidence in the United States, 2000-2019

Eye (Lond). 2024 Feb 13. doi: 10.1038/s41433-024-02959-9. Online ahead of print.

Authors

Basilica M Arockiaraj^{1

2}, Elizabeth K Cahoon¹, Michael R Sargen¹, Erping Long^{1

3}, Margaret A Tucker¹, Jim Z Mai⁴

Affiliations

¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA.
² School of Public Health, University of Maryland, College Park, MD, USA.
³ Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁴ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA. zhiming.mai@nih.gov.

PMID: 38351125
DOI: 10.1038/s41433-024-02959-9

Abstract

Background/objectives: Ocular melanoma is a rare, but deadly cancer. This large cancer registry study examines the associations between solar ultraviolet radiation (UVR) and incidence of different anatomical sites of ocular melanoma by sex, age, laterality, and race and ethnicity.

Methods: Incidence data were derived from 21 cancer registries in the US for the years 2000-2019. Satellite-based UVR estimates were linked to county of residence at diagnosis. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quartiles using Poisson models.

Results: UVR was not associated with total ocular melanoma (N = 18,089) comparing Q4 versus Q1 (IRR = 0.98; 95%CI:0.94,1.03; p-trend = 0.07) or conjunctival melanoma (IRR = 0.99; 95%CI:0.82,1.19; p-trend = 0.81). However, in analyses of continuous UVR (per 10 mW/m²), risks were reduced for total ocular melanoma (IRR = 0.97; 95% CI: 0.96, 0.99). Incidence was increased for ciliary body/iris melanoma in the highest UVR quartile (IRR = 1.63; 95%CI:1.43,1.87; p-trend < 0.0001) and remained increased in non-Hispanic White individuals only. Incidence was reduced for choroidal melanoma in the highest UVR quartile (IRR = 0.86; 95%CI:0.82,0.91; p-trend < 0.0001).

Conclusions: UVR may be associated with increased risk of ciliary body/iris melanoma. Reduced risk of choroidal melanoma may be due to higher diffuse UVR exposure to posterior ocular sites in locations at higher latitudes. Our results support and expand previous findings of associations of UVR using various surrogates on ocular melanoma risk and serve as a starting point for understanding the differences in the relationship between UVR and specific anatomical sites.