Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone

Indian J Lepr. Oct-Dec 1985;57(4):756-62.

Abstract

Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dapsone / administration & dosage
  • Dapsone / analogs & derivatives*
  • Dapsone / blood
  • Dapsone / chemical synthesis
  • Dapsone / metabolism
  • Dapsone / therapeutic use
  • Drug Evaluation, Preclinical
  • Leprosy / drug therapy*
  • Rabbits

Substances

  • 4,4'-disuccinoylaminodiphenyl sulfone
  • 4,4'-dibutyrylaminodiphenyl sulfone
  • Dapsone