Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy

Michael Chamberlin; Sophia Khan; Cristal Hernandez; Markku Miettinen; Jun S Wei; Javed Khan; John Glod; Lindsay Rowe; Aradhana Kaushal

doi:10.1159/000511073

Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy

Case Rep Oncol. 2021 Feb 9;14(1):17-23. doi: 10.1159/000511073. eCollection 2021 Jan-Apr.

Authors

Michael Chamberlin¹, Sophia Khan², Cristal Hernandez², Markku Miettinen³, Jun S Wei⁴, Javed Khan⁴, John Glod², Lindsay Rowe⁵, Aradhana Kaushal⁶

Affiliations

¹ Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
² Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
³ Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
⁴ Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
⁵ Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
⁶ Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.

Abstract

Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.

Keywords: Aneurysmal fibrous histiocytoma; Midostaurin; Pazopanib; Protein kinase C inhibitor; Radiation.

Publication types

Case Reports