Eight structurally diverse components with anti-acetylcholinesterase activity from Daphne bholua

Abstract

Eight structurally diverse components, including six undescribed ones, (±)-daphuarin A (1a/1b), daphuarin B (2), daphuarin D-E (4-6), together with a pair of new natural products (±)-daphuarin C (3a/3b) were isolated from the herb of Daphne bholua Buch.-Ham. ex D. Don. Their planar structures were elucidated by extensive spectroscopic analyses. The configurations were established with the assistance of quantum chemical calculations, together with the Custom DP4+ method. The inhibitory potentials of all isolates against acetylcholinesterase were evaluated.

Keywords: AChE activity; Bioinformatics analysis; Chiral separation; Daphne bholua; Phenylpropanoids; Thymelaeaceae.