Persistent gram-negative bloodstream infection increases the risk of recurrent bloodstream infection with the same species

Paa Kwesi Ankrah; Andrew Bock; Felicia Ruffin; Blake M Hanson; Cesar A Arias; Stacey A Maskarinec; Joshua Parsons; Vance G Fowler Jr; Joshua T Thaden

doi:10.1093/cid/ciae068

Persistent gram-negative bloodstream infection increases the risk of recurrent bloodstream infection with the same species

Clin Infect Dis. 2024 Feb 15:ciae068. doi: 10.1093/cid/ciae068. Online ahead of print.

Authors

Paa Kwesi Ankrah¹, Andrew Bock², Felicia Ruffin¹, Blake M Hanson^{3

4}, Cesar A Arias⁵, Stacey A Maskarinec¹, Joshua Parsons¹, Vance G Fowler Jr¹, Joshua T Thaden¹

Affiliations

¹ Division of Infectious Disease, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.
² Duke University School of Medicine, Durham, North Carolina, USA.
³ Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
⁴ Center for Infectious Diseases, Department of Epidemiology, UTHealth Houston School of Public Health, University of Texas Health Science Center, Houston, TX, USA.
⁵ Department of Medicine, Weill Cornell Medical College, New York, NY, USA.

PMID: 38366610
DOI: 10.1093/cid/ciae068

Abstract

The association between persistent gram-negative bloodstream infection (GN-BSI), or ongoing positive cultures, and recurrent GN-BSI has not been investigated. Among 992 adults, persistent GN-BSI was associated with increased recurrent GN-BSI with the same bacterial species and strain (6% vs 2%; p=0.04). Persistent GN-BSI may be a marker of complicated infection.

Keywords: bloodstream infection; gram-negative; recurrent; reinfection; relapse.