TIGIT: A potential immunotherapy target for gynecological cancers

Pathol Res Pract. 2024 Mar:255:155202. doi: 10.1016/j.prp.2024.155202. Epub 2024 Feb 7.

Abstract

Gynecological cancer represents a significant global health challenge, and conventional treatment modalities have demonstrated limited efficacy. However, recent investigations into immune checkpoint pathways have unveiled promising opportunities for enhancing the prognosis of patients with cancer. Among these pathways, TIGIT has surfaced as a compelling candidate owing to its capacity to augment the immune function of NK and T cells through blockade, thereby yielding improved anti-tumor effects and prolonged patient survival. Global clinical trials exploring TIGIT blockade therapy have yielded promising preliminary findings. Nevertheless, further research is imperative to comprehensively grasp the potential of TIGIT-based immunotherapy in optimizing therapeutic outcomes for gynecological cancers. This review primarily delineates the regulatory network and immunosuppressive mechanism of TIGIT, expounds upon its expression and therapeutic potential in three major gynecological cancers, and synthesizes the clinical trials of TIGIT-based cancer immunotherapy. Such insights aim to furnish novel perspectives and serve as reference points for subsequent research and clinical application targeting TIGIT in gynecological cancers.

Keywords: Gynecological cancer; Immune checkpoint; Immunotherapy; TIGIT.

Publication types

  • Review

MeSH terms

  • Genital Neoplasms, Female* / therapy
  • Humans
  • Immunotherapy
  • Receptors, Immunologic*
  • T-Lymphocytes

Substances

  • Receptors, Immunologic
  • TIGIT protein, human