Specificities of Japan by geography, culture, and low incidence for Toxoplasmosis were examined in this epidemiological study. 1 731 human sera were examined by several immunological tests but these results are related with Agglutination-Latex test. The sera came from North (Hokkaido), Middle (Tokyo area) and South (Okinawa). The ratio for the whole Japan towards Toxoplasmosis is 24.7% but the increase of antibodies with age is late: rate of positivity 4.6% up to 17 years old and nearly 30% after 30 years old. Cats, business, climate do not seem to influence the human infection. It is consumption of meat and particularly raw meat which influence the results: 40.8% positive results among eaters of raw meat and 22% among those not eating meat or eating it well cooked.