Sclerotherapy of the Post renal Transplant Lymphoceles: A Meta-Analysis

Transplant Proc. 2024 Mar;56(2):316-321. doi: 10.1016/j.transproceed.2024.01.055. Epub 2024 Feb 16.

Abstract

Purpose: This study evaluated the effectiveness of sclerotherapy in treating lymphoceles after kidney transplantation, focusing on factors such as recurrence rates and procedural success.

Materials and methods: Retrospective studies using sclerotherapy as the only form of treatment for postrenal transplant lymphoceles were included. All studies used percutaneous transcatheter sclerotherapy as treatment, and the success rate of the intervention was recorded. Sixty-one references were obtained by manually searching the MEDLINE (n = 20), Embase (n = 41), and Cochrane Library databases (n = 0) for retrospective research studies that included the keywords "sclerotherapy post renal transplant lymphoceles." After removing 3 duplicates, 50 of the remaining articles were excluded after the screening, and the remaining studies were extracted for demographic data and our primary outcome of the success rate of sclerotherapy.

Results: A descriptive analysis of the outcomes and complication rates associated with sclerotherapy interventions for lymphoceles is provided. A high degree of variation across the different studies was observed. According to the Kruskal-Wallis test, there was no correlation between the sclerosant used and the sclerotherapy complication rate (P = .472) or the success rate (P = .591). There was also no correlation between the gender of the patient and the success rate; however, there was a significant difference in the complication rate by gender (P < .005).

Conclusions: In conclusion, different sclerosant products have been used for therapy with no consensus on the most efficacious product because the success rate has been variable. In addition, the gender of the patient may influence the complication rates associated with sclerotherapy for lymphoceles in patients post-kidney transplant.

Publication types

  • Meta-Analysis

MeSH terms

  • Drainage / adverse effects
  • Humans
  • Kidney Transplantation* / adverse effects
  • Lymphocele* / etiology
  • Lymphocele* / therapy
  • Postoperative Complications / drug therapy
  • Retrospective Studies
  • Sclerosing Solutions / adverse effects
  • Sclerotherapy / adverse effects

Substances

  • Sclerosing Solutions