Applications of Cryoneurolysis in Chronic Pain Management: a Review of the Current Literature

Curr Pain Headache Rep. 2024 May;28(5):403-416. doi: 10.1007/s11916-024-01222-w. Epub 2024 Feb 19.


Purpose of review: The purpose of this review is to evaluate and summarize the literature investigating cryoneurolysis in the treatment of various chronic pain pathologies.

Recent findings: There is an increasing amount of interest in the use of cryoneurolysis in chronic pain, and various studies have investigated its use in lumbar facet joint pain, SI joint pain, post-thoracotomy syndrome, temporomandibular joint pain, chronic knee pain, phantom limb pain, neuropathic pain, and abdominal pain. Numerous retrospective studies and a more limited number of prospective, sham-controlled prospective studies suggest the efficacy of cryoneurolysis in managing these chronic pain pathologies with a low complication rate. However, more blinded, controlled, prospective studies comparing cryoneurolysis to other techniques are needed to clarify its relative risks and advantages.

Keywords: Chronic pain; Cryoablation; Cryoneurolysis; Neurolysis; Pain management; Technology.

Publication types

  • Review

MeSH terms

  • Chronic Pain* / surgery
  • Cryosurgery / methods
  • Cryotherapy / methods
  • Humans
  • Pain Management* / methods