Recent Advances in Topical Hemostatic Materials

ACS Appl Bio Mater. 2024 Mar 18;7(3):1362-1380. doi: 10.1021/acsabm.3c01144. Epub 2024 Feb 19.


Untimely or improper treatment of traumatic bleeding may cause secondary injuries and even death. The traditional hemostatic modes can no longer meet requirements of coping with complicated bleeding emergencies. With scientific and technological advancements, a variety of topical hemostatic materials have been investigated involving inorganic, biological, polysaccharide, and carbon-based hemostatic materials. These materials have their respective merits and defects. In this work, the application and mechanism of the major hemostatic materials, especially some hemostatic nanomaterials with excellent adhesion, good biocompatibility, low toxicity, and high adsorption capacity, are summarized. In the future, it is the prospect to develop multifunctional hemostatic materials with hemostasis and antibacterial and anti-inflammatory properties for promoting wound healing.

Keywords: Coagulation cascade reactions; Fibrin clots formation; Hemostatic materials; Platelet aggregation; Water absorption capacity.

Publication types

  • Review

MeSH terms

  • Blood Coagulation
  • Hemorrhage
  • Hemostasis
  • Hemostatics* / pharmacology
  • Hemostatics* / therapeutic use
  • Humans
  • Wound Healing


  • Hemostatics