Relation between a history of glaucoma and subjective happiness: the JPHC-Next study

BMJ Open Ophthalmol. 2024 Feb 19;9(1):e001553. doi: 10.1136/bmjophth-2023-001553.


Objective: This population-based, cross-sectional study was performed to investigate the relationship between a history of glaucoma and subjective happiness.

Methods and analysis: We conducted a cross-sectional questionnaire-based survey of 92 397 Japanese men and women aged 40-74 who participated in the Japan Public Health Center-based Prospective Study for the Next Generation study. A multivariable logistic regression model was used to estimate the ORs of glaucoma associated with subjective happiness and their two-sided 95% CIs.

Results: Among 40 727 men and 51 670 women, 1733 participants (635 men, 1098 women) had a history of glaucoma. The odds of unhappiness in male participants with a history of glaucoma were higher (OR 1.26; 95% CI 1.05 to 1.51) than in female participants (OR 1.05; 95% CI 0.90 to 1.23). In a subgroup analysis stratified by age, among participants with a history of glaucoma, males in the younger group (40-59 years) showed the most robust association with unhappiness (OR 1.40; 95% CI 1.04 to 1.88).

Conclusions: These findings suggest that a history of glaucoma is related with subjective unhappiness, especially in men.

Keywords: Glaucoma.

MeSH terms

  • Adult
  • Cross-Sectional Studies
  • Female
  • Glaucoma* / epidemiology
  • Happiness*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Surveys and Questionnaires