Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

Thanh Quang Nguyen; Bo Eun Heo; Seunghyeon Jeon; Anwesha Ash; Heehyun Lee; Cheol Moon; Jichan Jang

doi:10.3389/fmicb.2024.1331508

Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

Front Microbiol. 2024 Feb 6:15:1331508. doi: 10.3389/fmicb.2024.1331508. eCollection 2024.

Authors

Thanh Quang Nguyen¹, Bo Eun Heo¹, Seunghyeon Jeon¹, Anwesha Ash¹, Heehyun Lee¹, Cheol Moon², Jichan Jang¹

Affiliations

¹ Division of Life Science, Department of Bio & Medical Big Data (BK21 Four Program), Research Institute of Life Science, Gyeongsang National University, Jinju, Republic of Korea.
² Department of Clinical Laboratory Science, Semyung University, Jecheon, Republic of Korea.

Abstract

Mycobacterium abscessus, a leading cause of severe lung infections in immunocompromised individuals, poses significant challenges for current therapeutic strategies due to resistance mechanisms. Therefore, understanding the intrinsic and acquired antibiotic resistance of M. abscessus is crucial for effective treatment. This review highlights the mechanisms employed by M. abscessus to sustain antibiotic resistance, encompassing not only conventional drugs but also newly discovered drug candidates. This comprehensive analysis aims to identify novel entities capable of overcoming the notorious resistance exhibited by M. abscessus, providing insights for the development of more effective therapeutic interventions.

Keywords: Mycobacterium abscessus; drug resistance; efflux pump; intrinsic-extrinsic drug resistance; mycobacterium drug efficacy.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work is supported by a grant of the Ministry of Health & Welfare, Republic of Korea (HI22C136100 and 2020ER520601), funded by the grant 2020R1A2C100407714 and RS-2023-00266419 from the National Research Foundation (NRF) of Republic of Korea. This research was also supported by “Regional Innovation Strategy (RIS)” through the NRF funded by the Ministry of Education (MOE) (2021RIS001, 1345370811). TN, BH, SJ, and AA were supported by the BK21 Four Program. AA was sponsored by the Global Korea Scholarship program under the MOE in Korea.