Postirradiation soft tissue sarcoma occurring in breast cancer patients: report of seven cases and results of combination chemotherapy

J Surg Oncol. 1985 Mar;28(3):168-71. doi: 10.1002/jso.2930280304.


Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4-26 years. These cases conform well to established criteria for the diagnosis of radiation-induced sarcoma. Chemotherapy, consisting of the four-drug combination CYVADIC (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin-containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation-related sarcoma in primary or postoperative breast irradiation are discussed.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Breast Neoplasms / radiotherapy*
  • Cyclophosphamide / administration & dosage
  • Dacarbazine / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Humans
  • Middle Aged
  • Neoplasms, Radiation-Induced / etiology*
  • Radiotherapy / adverse effects*
  • Sarcoma / drug therapy
  • Sarcoma / etiology*
  • Soft Tissue Neoplasms / drug therapy
  • Soft Tissue Neoplasms / etiology*
  • Vincristine / administration & dosage


  • Vincristine
  • Dacarbazine
  • Doxorubicin
  • Cyclophosphamide

Supplementary concepts

  • CYVADIC protocol