Mepolizumab-induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma

Kamini Rakkar; Yik L Pang; Poojitha Rajasekar; Michael A Portelli; Robert J Hall; Rachel L Clifford; Dominick Shaw; Ian Sayers

doi:10.1164/rccm.202308-1477LE

Mepolizumab-induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma

Am J Respir Crit Care Med. 2024 May 15;209(10):1268-1272. doi: 10.1164/rccm.202308-1477LE.

Authors

Kamini Rakkar^{1

2}, Yik L Pang^{1

3}, Poojitha Rajasekar^{1

2}, Michael A Portelli^{1

2}, Robert J Hall^{1

2}, Rachel L Clifford^{1

2}, Dominick Shaw^{1

3}, Ian Sayers^{1

2}

Affiliations

¹ Centre for Respiratory Research, National Institute for Health Research Nottingham, Biomedical Research Centre, School of Medicine, Nottingham, United Kingdom.
² Nottingham University Biodiscovery Institute, Nottingham, United Kingdom; and.
³ City Hospital, University of Nottingham, Nottingham, United Kingdom.

PMID: 38386780
DOI: 10.1164/rccm.202308-1477LE

No abstract available

Publication types

Letter

MeSH terms

Adult
Anti-Asthmatic Agents / therapeutic use
Antibodies, Monoclonal, Humanized* / therapeutic use
Asthma* / drug therapy
Asthma* / genetics
DNA Methylation / drug effects
Epigenome
Female
Humans
Male
Middle Aged
Nasal Mucosa / drug effects
Transcriptome*

Publication types

MeSH terms

Grants and funding