Extensive Cutaneous-Mucosal and Muscular Involvement of Gamma/Delta Cutaneous T-Cell Lymphoma on 18 F-FDG PET/CT

Clin Nucl Med. 2024 May 1;49(5):e206-e207. doi: 10.1097/RLU.0000000000005135. Epub 2024 Feb 22.

Abstract

Gamma/delta T-cell lymphoma is a rare and aggressive subtype of primary cutaneous lymphoma. Clinical manifestations typically include the development of subcutaneous nodules and ulcerated plaques. Some forms present as panniculitis with hemophagocytic syndrome. Prognosis is bleak, with a 10% 5-year survival rate. In this report, we present the case of a 20-year-old man from French Polynesia, referred for 18 F-FDG PET/CT because of the progressive worsening of febrile cutaneous-mucosal infiltration on the face persisting for 1 month. PET examination guided a biopsy from the right deltoid muscle, and expert histological analysis confirmed a CD8 + not otherwise specified T-cell lymphoma, granzyme+ and TCR gamma/delta.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Fluorodeoxyglucose F18
  • Humans
  • Lymphoma, T-Cell* / pathology
  • Lymphoma, T-Cell, Cutaneous* / diagnostic imaging
  • Male
  • Panniculitis* / pathology
  • Positron Emission Tomography Computed Tomography
  • Skin Neoplasms* / diagnostic imaging
  • Skin Neoplasms* / pathology
  • T-Lymphocytes / pathology
  • Young Adult

Substances

  • Fluorodeoxyglucose F18