The mRNA-LNP vaccines - the good, the bad and the ugly?

Front Immunol. 2024 Feb 8:15:1336906. doi: 10.3389/fimmu.2024.1336906. eCollection 2024.


The mRNA-LNP vaccine has received much attention during the COVID-19 pandemic since it served as the basis of the most widely used SARS-CoV-2 vaccines in Western countries. Based on early clinical trial data, these vaccines were deemed safe and effective for all demographics. However, the latest data raise serious concerns about the safety and effectiveness of these vaccines. Here, we review some of the safety and efficacy concerns identified to date. We also discuss the potential mechanism of observed adverse events related to the use of these vaccines and whether they can be mitigated by alterations of this vaccine mechanism approach.

Keywords: Quo Vadis; adverse event; mRNA vaccine; side effect; suppression.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • COVID-19 Vaccines* / adverse effects
  • Humans
  • Pandemics
  • RNA, Messenger
  • mRNA Vaccines*


  • mRNA Vaccines
  • COVID-19 Vaccines
  • RNA, Messenger