PC4: A new regulator of cyclin D1 transcript levels

J Cell Biol. 2024 Mar 4;223(3):e202401056. doi: 10.1083/jcb.202401056. Epub 2024 Feb 23.


The expression of cyclin proteins is tightly regulated during the cell cycle, to allow precise activation of cyclin-dependent kinases. In this issue, Pan et al. (https://doi.org/10.1083/jcb.202308066) identify an RNA-binding protein, PC4, as a regulator of cyclin D1 mRNA stability in hepatocellular carcinoma cells. This study provides a new mechanism regulating the levels of a key cell cycle protein, cyclin D1, in human cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cell Cycle
  • Cell Cycle Proteins / metabolism
  • Cell Line, Tumor
  • Cyclin D1* / metabolism
  • Cyclin-Dependent Kinases / metabolism
  • DNA-Binding Proteins* / genetics
  • DNA-Binding Proteins* / metabolism
  • Humans
  • Phosphorylation
  • RNA Stability*
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism


  • Cell Cycle Proteins
  • Cyclin D1
  • Cyclin-Dependent Kinases
  • SUB1 protein, human
  • DNA-Binding Proteins
  • Transcription Factors