Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties

P D Singh; J H Johnson; C A Aklonis; K Bush; S M Fisher; J O'Sullivan

doi:10.7164/antibiotics.38.706

Two new inhibitors of phospholipase A2 produced by Penicillium chermesinum. Taxonomy, fermentation, isolation, structure determination and biological properties

J Antibiot (Tokyo). 1985 Jun;38(6):706-12. doi: 10.7164/antibiotics.38.706.

Authors

P D Singh, J H Johnson, C A Aklonis, K Bush, S M Fisher, J O'Sullivan

PMID: 3839502
DOI: 10.7164/antibiotics.38.706

Abstract

Plastatin and the known fungal metabolite, luteosporin, have been isolated from fermentations of Penicillium chermesinum as inhibitors of porcine pancreatic phospholipase A2 (PLA2). Structure 1 for plastatin was deduced from its spectroscopic properties. Plastatin and luteosporin inhibited pancreatic PLA2 competitively with Ki values of 0.89 microM and 12.8 microM, respectively. PLA2 preparations from Naja naja and Crotalus adamanteus were not significantly inhibited by plastatin and luteosporin.

MeSH terms

Chemical Phenomena
Chemistry
Fermentation
Kinetics
Magnetic Resonance Spectroscopy
Naphthoquinones / isolation & purification*
Naphthoquinones / pharmacology
Penicillium / classification
Penicillium / metabolism*
Phospholipases / antagonists & inhibitors*
Phospholipases A / antagonists & inhibitors*
Phospholipases A2

Substances

Naphthoquinones
luteosporin
plastatin
Phospholipases
Phospholipases A
Phospholipases A2