Circadian and daily rhythms of disease vector mosquitoes

Abstract

Mosquitoes express a rich repertoire of daily 24-hour rhythms in biochemistry, physiology, and behavior. The nocturnal Anopheles and Culex and diurnal Aedes mosquitoes are major vectors of human disease, transmitting parasites and arboviruses, such as malaria and dengue. In this review, we explore the role that 24-hour diel and circadian rhythms play in shaping the temporal life of the mosquito. We focus on recent advances in our understanding of behavioral rhythms, focusing on locomotor/flight activity, host-seeking, biting/blood feeding, and mating. We examine the molecular circadian clock, photocycle, and light signals, which in combination shape the mosquito 24-hour temporal program. We address species- and sex-specific differences and highlight important selective pressures from dynamically changing environments. This work also provides new insights into disease transmission, insect control, and future experimental design.