Peptide YY (PYY), a potent orexigenic agent

Brain Res. 1985 Aug 19;341(1):200-3. doi: 10.1016/0006-8993(85)91490-8.


Peptide YY (PYY) enhances feeding and drinking more potently than does neuropeptide Y after central administration. Chronic administration of PYY every 6 h for 48 h causes massive food ingestion. Tolerance to this effect of PYY does not appear to develop. This data suggests that PYY is one of the most potent orexigenic substances yet to be identified. PYY may play a role in the pathogenesis of bulimic syndromes.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Appetite / drug effects*
  • Drinking / drug effects
  • Eating / drug effects
  • Hyperphagia / etiology
  • Male
  • Nerve Tissue Proteins / pharmacology
  • Neuropeptide Y
  • Peptide YY
  • Peptides / pharmacology*
  • Rats
  • Rats, Inbred Strains


  • Nerve Tissue Proteins
  • Neuropeptide Y
  • Peptides
  • Peptide YY