Rare Co-occurrence of Spinal Cord Hemorrhage from Radiation-induced Cavernous Hemangioma and Classical Hodgkin Lymphoma Post-transplant Lymphoproliferative Disorder

Takahiro Shimizu; Yu Nagashima; Takashi Matsukawa; Akihiko Mitsutake; Mizuho Kawai; Yurino Horiuchi; Keishi Yokoyama; Kensuke Takaoka; Yuya Kurihara; Kazuhiro Toyama; Kaori Sakuishi; Mineo Kurokawa; Tatsushi Toda

doi:10.2169/internalmedicine.2898-23

Rare Co-occurrence of Spinal Cord Hemorrhage from Radiation-induced Cavernous Hemangioma and Classical Hodgkin Lymphoma Post-transplant Lymphoproliferative Disorder

Intern Med. 2024 Feb 26. doi: 10.2169/internalmedicine.2898-23. Online ahead of print.

Authors

Affiliations

¹ Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.
² Department of Biomedical Photonics & Engineering, Hamamatsu University School of Medicine, Japan.
³ Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, Japan.
⁴ Department of Neurology, Teikyo University Chiba Medical Center, Japan.
⁵ Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, Japan.

PMID: 38403773
DOI: 10.2169/internalmedicine.2898-23

Abstract

Post-transplant lymphoproliferative disorders (PTLDs) are lymphoproliferative diseases that occur after solid organ transplantation or hematopoietic stem cell transplantation (HSCT). The development of PTLD is often associated with reactivation of Epstein-Barr virus (EBV). A 26-year-old woman with a history of HSCT and total-body irradiation developed spinal cord hemorrhage from a radiation-induced cavernous hemangioma (RICH) shortly after the development of classical Hodgkin lymphoma PTLD with EBV reactivation. Although little is known about the factors leading to hemorrhagic events from spinal cord RICH, we suspect that EBV reactivation may have been a factor contributing to the hemorrhage in the present case.

Keywords: Epstein-Barr virus; Post-transplant lymphoproliferative disorders; radiation-induced cavernous hemangioma; spinal cord hemorrhage.