The Impossible Dream - Panmixia

Twin Res Hum Genet. 2024 Feb 27:1-5. doi: 10.1017/thg.2024.6. Online ahead of print.

Abstract

This study starts with a simple model by which Hardy-Weinberg proportions are attained in a single generation while maintaining gene frequencies. The question of differentiating between random and non-random mating is explored by simulation. Sample mating proportions are generated using the model as base. The difficulty of differentiating between random and non-random mating is illustrated.

Keywords: Estimation standard error; Hardy-Weinberg law; Quasi-random mating; Simulated coupling parameter.