Idiopathic aseptic facial granuloma: A retrospective study of 43 cases

Pediatr Dermatol. 2024 Mar-Apr;41(2):243-246. doi: 10.1111/pde.15571. Epub 2024 Feb 27.

Abstract

Background: Idiopathic aseptic facial granuloma (IAFG) is an underrecognized pediatric skin disease, currently considered within the spectrum of rosacea. It usually manifests as a solitary, reddish, asymptomatic nodule on the cheek that resolves spontaneously.

Methods: Retrospective and descriptive observational study of 43 pediatric patients with a clinical diagnosis of IAFG, followed between 2004 and 2022, at two general hospitals in Argentina.

Results: IAFG predominated in girls (65%) and the average age of onset was about 6 years. A single asymptomatic nodule was seen in 79% of patients. The most common localization was the cheek (58%) followed by lower eyelids (41%). Family history of rosacea was present in 16% of patients. A concomitant diagnosis of rosacea and periorificial dermatitis was made in 14% and 9% of our population, respectively. Past or present history of chalazia was detected in 42% of the children. IAFG diagnosis was mainly clinical (88% of cases). Oral antibiotics were the most common indicated treatment (84%). Complete healing was achieved by the majority, but 18% of those with eyelid compromise healed with scars.

Conclusions: IAFG is a benign pediatric condition that physicians should recognize in order to manage correctly. We herein refer to a particular morphologic aspect of IAFG lesions affecting the lower eyelids, where nodules adopt a linear distribution and have a higher probability of involute leaving a scar. Also, we consider that the concomitant findings of rosacea, periorificial dermatitis and chalazia in our patients, reinforce the consideration of IAFG within the spectrum of rosacea.

Keywords: chalazion; facial nodule; idiopathic aseptic facial granuloma; pediatric rosacea.

Publication types

  • Observational Study

MeSH terms

  • Chalazion* / complications
  • Chalazion* / diagnosis
  • Child
  • Connective Tissue Diseases*
  • Dermatitis*
  • Facial Dermatoses* / diagnosis
  • Facial Dermatoses* / drug therapy
  • Facial Dermatoses* / pathology
  • Female
  • Granuloma / diagnosis
  • Granuloma / drug therapy
  • Humans
  • Retrospective Studies
  • Rosacea* / diagnosis
  • Rosacea* / drug therapy
  • Rosacea* / epidemiology