Transient infantile lingual leukoplakia: An underrecognized cause of white tongues in infancy

Pediatr Dermatol. 2024 May-Jun;41(3):476-479. doi: 10.1111/pde.15576. Epub 2024 Feb 27.

Abstract

We have observed a distinct phenomenon of transient oral lingual leukoplakia in infancy and report 22 healthy infants with gray-white plaques on the dorsal tongue with sparing of the tip from four medical centers in three countries. The onset of the eruption ranged from 1 week to 7 months of life and resolved in 19 patients (86%, with 3 patients lost to follow-up). None of the eight patients examined at 1 year of age had residual findings. We believe this is a common entity that can be distinguished from oral candidiasis on clinical and/or laboratory examination and name this entity "transient infantile lingual leukoplakia."

Keywords: infant; oral leukoplakia; tongue; white plaque.

Publication types

  • Multicenter Study

MeSH terms

  • Diagnosis, Differential
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Leukoplakia, Oral* / diagnosis
  • Leukoplakia, Oral* / pathology
  • Male
  • Tongue / pathology
  • Tongue Diseases / diagnosis
  • Tongue Diseases / pathology