Abierixin, a new polyether antibiotic. Production, structural determination and biological activities

J Antibiot (Tokyo). 1985 Dec;38(12):1655-63. doi: 10.7164/antibiotics.38.1655.

Abstract

A new polyether antibiotic, abierixin, was found in the mycelium of a culture broth of nigericin-producing Streptomyces albus NRRL B-1865. Abierixin was extracted with organic solvents and purified by column chromatography and HPLC. The structure of abierixin was determined by FAB/MS/MS and CI/MS/MS and 1H and 13C NMR spectrometries. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity. Nigericin biosynthesis from abierixin is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Chemical Phenomena
  • Chemistry
  • Chickens
  • Eimeria / drug effects
  • Fermentation
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Nigericin / metabolism
  • Pyrans / isolation & purification
  • Pyrans / pharmacology
  • Streptomyces / metabolism*

Substances

  • Anti-Bacterial Agents
  • Pyrans
  • abierixin
  • Nigericin