Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone

V Prikrylová; H Lipavská; J V Jizba; J Fuska; M Podojil; Z Vanĕk

doi:10.7164/antibiotics.38.1714

Synthesis and biological activity of (7S)-O-epoxyalkyl derivatives of daunomycinone

J Antibiot (Tokyo). 1985 Dec;38(12):1714-8. doi: 10.7164/antibiotics.38.1714.

Authors

V Prikrylová, H Lipavská, J V Jizba, J Fuska, M Podojil, Z Vanĕk

PMID: 3841537
DOI: 10.7164/antibiotics.38.1714

Abstract

Synthesis and antibacterial activity of a number of 7-O-epoxyalkyl derivatives of daunomycinone prepared from 7-O-alkenyl derivatives of daunomycinone are described along with their inhibitory effect on leukemia P 388 cells.

MeSH terms

Animals
Antibiotics, Antineoplastic / chemical synthesis*
Antibiotics, Antineoplastic / pharmacology
Bacteria / drug effects
Leukemia P388 / metabolism
Naphthacenes / chemical synthesis*
Naphthacenes / pharmacology

Substances

Antibiotics, Antineoplastic
Naphthacenes
daunomycinone