Applying Noninvasive Ventilation in Treatment of Acute Exacerbation of COPD Using Evidence-Based Interprofessional Clinical Practice

Chest. 2024 Jun;165(6):1469-1480. doi: 10.1016/j.chest.2024.02.040. Epub 2024 Feb 28.


When administered as first-line intervention to patients admitted with acute hypercapnic respiratory failure secondary to COPD exacerbation in conjunction with guideline-recommended therapies, noninvasive ventilation (NIV) has been shown to reduce mortality and endotracheal intubation. Opportunities to increase uptake of NIV continue to exist despite inclusion of this therapy in clinical guidelines. Identifying patients appropriate for NIV, and subsequently providing close monitoring to determine an improvement in clinical condition involves a team consisting of physician, nurse, and respiratory therapist in institutions that successfully implement NIV. We describe to our knowledge the first known evidence-based algorithm speaking to initiation, titration, monitoring, and weaning of NIV in treatment of acute exacerbation of COPD that incorporates the necessary interprofessional collaboration among physicians, nurses, and respiratory therapists caring for these patients.

Keywords: COPD; acute exacerbation of COPD; interprofessional team; noninvasive ventilation.

Publication types

  • Review

MeSH terms

  • Algorithms
  • Evidence-Based Medicine
  • Humans
  • Noninvasive Ventilation* / methods
  • Patient Care Team / organization & administration
  • Pulmonary Disease, Chronic Obstructive* / complications
  • Pulmonary Disease, Chronic Obstructive* / therapy
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / therapy