Objectives: To analyze the status and temporal changes of disability-adjusted life year (DALY) for stomach and colorectal cancers among registered permanent residents in Changning District of Shanghai Municipality, and provide scientific basis for the prevention and treatment of stomach and colorectal cancers in this district. Methods: Using the cancer registration data of stomach and colorectal cancers from 2002 to 2019, we estimated the indices such as the DALYs, the DALY crude rates, the age-standardized DALY rates, etc. Then we used the Joinpoint regression model to calculate the average annual percent change (AAPC) and annual percent change (APC) to explore the temporal variations in different periods. Results: The DALYs of stomach and colorectal cancers in Changning District from 2002 to 2019 were 55 931 person years and 65 252 person years, respectively. The crude rates of DALY were 512.16/105 and 597.51/105, respectively. We observed a higher disease burden in men than in women, and the peak rate of DALY in stomach cancer was in the 75-79 years age group, while in colorectal cancer the rate was in the 85-years-or-older age group. Joinpoint regression analysis showed that from 2002 to 2019, the age-standardized DALY rate of stomach cancer showed a downward trend (AAPC=-3.86%, P＜0.05), while the trend of colorectal cancer was not statistically significant(AAPC=-0.08%, P＞0.05). However, the trends in the age-standardized DALY rates of colorectal cancer were different between males and females, with males showing an upward trend (AAPC=1.24%, P＜0.05) and females showing a downward trend (AAPC=-1.67%, P＜0.05). Conclusions: The DALY of stomach and colorectal cancers in Changning District of Shanghai showed a decreasing trend. Males and the middle-aged and elderly populations are still the key targets for disease prevention and control in this district.
目的： 分析上海市长宁区户籍居民胃癌和结直肠癌伤残调整寿命年（DALY）的现况及其变化趋势，为长宁区胃癌和结直肠癌的防治提供科学依据。 方法： 利用2002—2019年上海市长宁区肿瘤登记数据，估算该地居民胃癌和结直肠癌的DALYs、粗DALY率、标化DALY率等指标，采用Joinpoint回归分析计算标化率的年度变化百分比（APC）和年均变化百分比（AAPC），描述其不同阶段的时间变化趋势。 结果： 2002—2019年长宁区胃癌和结直肠癌的DALYs分别为55 931人年和65 252人年，粗DALY率分别为512.16/10万和597.51/10万；男性疾病负担高于女性，胃癌粗DALY率峰值分布在75～79岁组，结直肠癌粗DALY率峰值分布在85岁以上组。Joinpoint回归分析显示，2002—2019年长宁区胃癌标化DALY率呈下降趋势（AAPC=-3.86%，P＜0.05），结直肠癌标化DALY率变化趋势无统计学意义（AAPC=-0.08%，P＞0.05），但结直肠癌标化DALY率在男女性中变化趋势不同，男性呈上升趋势（AAPC=1.24%，P＜0.05），女性呈下降趋势（AAPC=-1.67%，P＜0.05）。 结论： 上海市长宁区居民的胃癌和结直肠癌DALY整体上有所下降，男性及中老年人群仍是防治重点。.