[Investigation of a French cohort of neonatal anoxo-ischemic encephalopathy in the era of therapeutic hypothermia: Questions and answers]

Thierry Debillon; Jonathan Beck; Isabelle Guellec; Antoine Vilotitch; Véronique Pierrat; Olivier Baud; Loïc Sentilhes; Gilles Kayem; Anne Ego

doi:10.1016/j.gofs.2024.02.025

[Investigation of a French cohort of neonatal anoxo-ischemic encephalopathy in the era of therapeutic hypothermia: Questions and answers]

Gynecol Obstet Fertil Senol. 2024 Feb 28:S2468-7189(24)00080-1. doi: 10.1016/j.gofs.2024.02.025. Online ahead of print.

[Article in French]

Authors

Thierry Debillon¹, Jonathan Beck², Isabelle Guellec³, Antoine Vilotitch⁴, Véronique Pierrat⁵, Olivier Baud⁶, Loïc Sentilhes⁷, Gilles Kayem⁸, Anne Ego⁹

Affiliations

¹ Service de réanimation et médecine néonatale, CHU Grenoble Alpes, 38000 Grenoble, France; Département de santé publique, université de Grenoble Alpes, CNRS, institut d'ingénierie et de management Grenoble Alpes, TIMC-IMAG, 38000 Grenoble, France. Electronic address: TDebillon@chu-grenoble.fr.
² Service de médecine et réanimation néonatale, réanimation soins continus pédiatriques, CHU de Reims, bâtiments Alix de Champagne et American Memorial Hospital II, 51100 Reims, France.
³ Service de réanimation néonatale, CHU de Nice, université de Nice Cote d'Azur, 06000 Nice, France; Obstetrical Perinatal and Pediatric Epidemiology Research Team, université Paris Cité, CRESS, EPOPE, Inserm, INRAE, 75004 Paris, France.
⁴ University de Grenoble Alpes, unité de Data Engineering, Pôle de santé publique, CHU Grenoble Alpes, 38000 Grenoble, France.
⁵ Obstetrical Perinatal and Pediatric Epidemiology Research Team, université Paris Cité, CRESS, EPOPE, Inserm, INRAE, 75004 Paris, France; Département de néonatalogie, CHI de Créteil, 94000 Créteil, France.
⁶ Division de néonatalogie, département de pédiatrie, université de Genève, Genève, Suisse.
⁷ Département de gynécologie et obstétrique, hôpital universitaire de Bordeaux, 33000 Bordeaux, France.
⁸ Obstetrical Perinatal and Pediatric Epidemiology Research Team, université Paris Cité, CRESS, EPOPE, Inserm, INRAE, 75004 Paris, France; Département d'obstétrique et de gynécologie, hôpital Trousseau, Sorbonne université, Assistance publique-Hôpitaux de Paris, 75012 Paris, France.
⁹ Département de santé publique, université de Grenoble Alpes, CNRS, institut d'ingénierie et de management Grenoble Alpes, TIMC-IMAG, 38000 Grenoble, France; Inserm CIC U1406, 38000 Grenoble, France.

PMID: 38428637
DOI: 10.1016/j.gofs.2024.02.025

Abstract

Objective: To improve knowledge of neonatal hypoxic-ischemic encephalopathy, a prospective, nationwide, population-based cohort of affected children is being set up between September 2015 and March 2017.

Methods: During this period, 794 cases are collected, with information on pregnancy, delivery, neonatal stay and outcome at the end of hospitalization. Clinical and parental questionnaire follow-up is planned until the child is 4 years old.

Results: This article presents the clinical presentation of the newborns included, the analysis of factors associated with short-term outcome at hospital discharge and the organizational factors associated with treatment with therapeutic hypothermia.

Conclusion: These data illustrate the value of a prospective cohort to analyze the management of anoxo-ischemic encephalopathy in France.

Keywords: Devenir à court terme; Encéphalopathie néonatale; Facteur de risque; Hypothermie thérapeutique; Neonatal encephalopathy; Optimal care; Risk factors; Short-term outcome; Soins optimaux; Therapeutic hypothermia.

Publication types

English Abstract