Brain structural changes and molecular analyses in children with benign epilepsy with centrotemporal spikes

Heng Liu; Duoli Chen; Chengxiang Liu; Peng Liu; Hua Yang; Hong Lu

doi:10.1038/s41390-024-03118-2

Brain structural changes and molecular analyses in children with benign epilepsy with centrotemporal spikes

Pediatr Res. 2024 Mar 2. doi: 10.1038/s41390-024-03118-2. Online ahead of print.

Authors

Heng Liu^#^{1

2}, Duoli Chen^#³, Chengxiang Liu³, Peng Liu³, Hua Yang⁴, Hong Lu⁵

Affiliations

¹ Department of Radiology, The Seventh People's Hospital of Chongqing, The Central Hospital Affiliated to Chongqing University of Technology, Chongqing, China. zmcliuh@163.com.
² Department of Radiology, The Affiliated Hospital of Zunyi Medical University, Zunyi, China. zmcliuh@163.com.
³ School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, China.
⁴ Department of Medical Imaging, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China. 13527547568@163.com.
⁵ Department of Radiology, The Seventh People's Hospital of Chongqing, The Central Hospital Affiliated to Chongqing University of Technology, Chongqing, China. 471739847@qq.com.

^# Contributed equally.

PMID: 38431664
DOI: 10.1038/s41390-024-03118-2

Abstract

Background: Benign epilepsy with centrotemporal spikes (BECTS) is a common childhood epilepsy syndrome, accompanied by behavioral problems and cognitive impairments. Previous studies of BECTS-related brain structures applied univariate analysis and showed inconsistent results. And neurotransmitter patterns associated with brain structural alterations were still unclear.

Methods: Structural images of twenty-one drug-naïve children with BECTS and thirty-five healthy controls (HCs) were scanned. Segmented gray matter volume (GMV) images were decomposed into independent components (ICs) using the source-based morphometry method. Then spatial correlation analyses were applied to examine possible relationships between GMV changes and neurotransmitter systems.

Results: Compared with HCs, drug-naïve children with BECTS showed increased volume in one GMV component (IC7), including bilateral precentral gyrus, bilateral supplementary motor area, left superior frontal cortex, bilateral middle/ inferior frontal cortex and bilateral anterior/ middle cingulate cortex. A positive correlation was observed between one GMV component (IC6) and seizure frequency. There were significantly positive correlations between abnormal GMV in IC7 and serotonergic, GABAergic and glutamatergic systems.

Conclusion: These findings provided further evidence of changed GMV in drug-naïve children with BECTS related to their behavioral problems and cognitive impairments, and associated neurotransmitters which could help to better understand neurobiological mechanisms and underlying molecular mechanisms of BECTS.

Impact: The article provides further evidence of changed gray matter volume in drug-naïve children with BECTS related to their behavioral problems and cognitive impairments as well as associated neurotransmitters. Most literature to date has applied univariate analysis and showed inconsistent results, and neurotransmitter patterns associated with brain structural alterations were still unclear. Therefore, this article uses multivariate method and JuSpace toolbox to fill the gap. Significantly increased gray matter volume was found in drug-naïve children with BECTS compared with healthy controls. Abnormal gray matter volume was significantly correlated with clinical data and specific neurotransmitters.