Taurine induces hormesis in multiple biological models: May have transformative implications for overall societal health

Edward J Calabrese; Peter Pressman; A Wallace Hayes; Rachna Kapoor; Gaurav Dhawan; Evgenios Agathokleous; Vittorio Calabrese

doi:10.1016/j.cbi.2024.110930

Taurine induces hormesis in multiple biological models: May have transformative implications for overall societal health

Chem Biol Interact. 2024 Apr 1:392:110930. doi: 10.1016/j.cbi.2024.110930. Epub 2024 Mar 1.

Authors

Edward J Calabrese¹, Peter Pressman², A Wallace Hayes³, Rachna Kapoor⁴, Gaurav Dhawan⁵, Evgenios Agathokleous⁶, Vittorio Calabrese⁷

Affiliations

¹ School of Public Health and Health Sciences, Department of Environmental Health, Morrill I-N344, University of Massachusetts, Amherst, MA, 01003, USA. Electronic address: edwardc@umass.edu.
² University of Maine, 5728 Fernald Hall, Room 201, Orono, ME, 04469, USA. Electronic address: peter.pressman@maine.edu.
³ Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL, USA. Electronic address: awallacehayes@comcast.net.
⁴ Saint Francis Hospital and Medical Center, Hartford, CT, USA. Electronic address: dr.rachnakapoor23@gmail.com.
⁵ Sri Guru Ram Das (SGRD), University of Health Sciences, Amritsar, India. Electronic address: drgdhawan@icloud.com.
⁶ School of Ecology and Applied Meteorology, Nanjing University of Information Science & Technology, Nanjing, 210044, China. Electronic address: evgenios@nuist.edu.cn.
⁷ Department of Biomedical and Biotechnological Sciences, School of Medicine University of Catania, Via Santa Sofia 97, Catania, 95123, Italy. Electronic address: calabres@unict.it.

PMID: 38432405
DOI: 10.1016/j.cbi.2024.110930

Abstract

This paper represents the first integrative assessment and documentation of taurine-induced hormetic effects in the biological and biomedical areas, their dose response features, mechanistic frameworks, and possible public health, therapeutic and commercial applications. Taurine-induced hormetic effects are documented in a wide range of experimental models, cell types and for numerous biological endpoints, with most of these experimental findings being reported within the past five years. It is suggested that the concept of hormesis may have a transformative effect on taurine research and its public health and therapeutic applications.

Keywords: Adaptive response; Biphasic dose response; Hormesis; Stem cells; Stress response; Taurine.

Publication types

Review

MeSH terms

Hormesis*
Models, Biological*