Neutrophil extracellular traps inhibit osteoclastogenesis

Biochem Biophys Res Commun. 2024 Apr 23:705:149743. doi: 10.1016/j.bbrc.2024.149743. Epub 2024 Feb 29.


Neutrophil extracellular traps (NETs) released by neutrophils upon inflammation or infection, act as an innate immune defense against pathogens. NETs also influence inflammatory responses and cell differentiation in host cells. Osteoclasts, which are derived from myeloid stem cells, are critical for the bone remodeling by destroying bone. In the present study, we explores the impact of NETs, induced by the inflammatory agent calcium ionophore A23187, on the differentiation and activation of osteoclasts, potentially through suppressing RANK expression. Our results collectively suggested that the inhibition of RANKL-mediated osteoclastogenesis by NETs might lead to the suppression of excessive bone resorption during inflammation.

Keywords: Bone resorption; Calcium ionophore A23187; Neutrophil extracellular trap; Osteoclast; Osteoclastogenesis.

MeSH terms

  • Bone Resorption*
  • Cell Differentiation
  • Extracellular Traps*
  • Humans
  • Inflammation
  • Neutrophils
  • Osteoclasts
  • Osteogenesis
  • RANK Ligand


  • RANK Ligand