Effects of Intravenous Infusion of Iodine Contrast Media on the Tracheal Diameter and Lung Volume Measured with Deep Learning-Based Algorithm

Koichiro Yasaka; Hiroyuki Saigusa; Osamu Abe

doi:10.1007/s10278-024-01071-4

Effects of Intravenous Infusion of Iodine Contrast Media on the Tracheal Diameter and Lung Volume Measured with Deep Learning-Based Algorithm

J Imaging Inform Med. 2024 Mar 6. doi: 10.1007/s10278-024-01071-4. Online ahead of print.

Authors

Koichiro Yasaka¹, Hiroyuki Saigusa², Osamu Abe²

Affiliations

¹ Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. koyasaka@gmail.com.
² Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

PMID: 38448759
DOI: 10.1007/s10278-024-01071-4

Abstract

This study aimed to investigate the effects of intravenous injection of iodine contrast agent on the tracheal diameter and lung volume. In this retrospective study, a total of 221 patients (71.1 ± 12.4 years, 174 males) who underwent vascular dynamic CT examination including chest were included. Unenhanced, arterial phase, and delayed-phase images were scanned. The tracheal luminal diameters at the level of the thoracic inlet and both lung volumes were evaluated by a radiologist using a commercial software, which allows automatic airway and lung segmentation. The tracheal diameter and both lung volumes were compared between the unenhanced vs. arterial and delayed phase using a paired t-test. The Bonferroni correction was performed for multiple group comparisons. The tracheal diameter in the arterial phase (18.6 ± 2.4 mm) was statistically significantly smaller than those in the unenhanced CT (19.1 ± 2.5 mm) (p < 0.001). No statistically significant difference was found in the tracheal diameter between the delayed phase (19.0 ± 2.4 mm) and unenhanced CT (p = 0.077). Both lung volumes in the arterial phase were 4131 ± 1051 mL which was significantly smaller than those in the unenhanced CT (4332 ± 1076 mL) (p < 0.001). No statistically significant difference was found in both lung volumes between the delayed phase (4284 ± 1054 mL) and unenhanced CT (p = 0.068). In conclusion, intravenous infusion of iodine contrast agent transiently decreased the tracheal diameter and both lung volumes.

Keywords: CT; Contrast media; Deep learning; Lung volume; Tracheal diameter.