RyR2 phosphorylation alters dyad architecture

Ben Short

doi:10.1085/jgp.202413569

RyR2 phosphorylation alters dyad architecture

J Gen Physiol. 2024 Apr 1;156(4):e202413569. doi: 10.1085/jgp.202413569. Epub 2024 Mar 7.

Author

Ben Short¹

Affiliation

¹ Science Writer, Rockefeller University Press , New York, NY, USA.

Abstract

JGP study (Asghari et al. 2024. J. Gen. Physiol.https://doi.org/10.1085/jgp.202213108) indicates that β-adrenergic signaling enlarges dyads and reorganizes RyR2 tetramers in cardiomyocytes.

MeSH terms

Myocytes, Cardiac*
Phosphorylation
Ryanodine Receptor Calcium Release Channel* / chemistry
Signal Transduction

Substances

Ryanodine Receptor Calcium Release Channel