"And it was the worst possible result, because it actually worked:" An interview with Richard Harland

Cells Dev. 2024 Mar 5:203910. doi: 10.1016/j.cdev.2024.203910. Online ahead of print.


One hundred years ago, Hilde Mangold and Hans Spemann published their seminal paper on what came to be known as The Organizer, but seven decades would pass before the molecular basis of this remarkable phenomenon was revealed. Richard Harland and his laboratory played a key role in that discovery, and in this interview he discusses not just the science and the people but also other important factors like mental health and luck.

Keywords: BMP antagonist; Neural induction; Noggin; Richard Harland; Spemann-Mangold Organizer.