Liquid biopsy is gradually being applied in the clinical diagnosis and treatment of lung cancer. At present, with the development of metabolomics, more and more metabolic biomarkers are considered as potential sensitive markers reflecting the occurrence and development of tumors. This article summarizes the changes in the main metabolic pathways of lung cancer, including glucose metabolism, amino acid metabolism, lipid metabolism, sphingolipid metabolism, glycerophospholipid metabolism, and purine metabolism. Meanwhile, this article reviews the role of metabolic biomarkers in the early diagnosis of lung cancer, predicting disease progression, and evaluating the efficacy of chemotherapy and immunotherapy, aiming to provide effective biomarkers for tumor diagnosis and treatment. .
【中文题目：肿瘤代谢标志物在肺癌液体活检中 的研究进展】 【中文摘要：液体活检被逐渐应用于肺癌临床诊疗中。目前，随着代谢组学的发展，越来越多代谢标志物被认为是潜在的反映肿瘤发生发展的敏感标志物。本文概括了肺癌主要代谢途径的改变，包括葡萄糖代谢、氨基酸代谢、脂质代谢、鞘脂代谢、甘油磷脂代谢和嘌呤代谢。同时，本文综述了代谢标志物在肺癌早期诊断、预测疾病进展、评估化疗与免疫治疗疗效的作用，旨在为肿瘤诊疗提供有效的标志物。 】 【中文关键词：肺肿瘤；代谢标志物；液体活检；代谢组学】.
Keywords: Liquid biopsy; Lung neoplasms; Metabolic biomarker; Metabolomics.